Caister Academic Press

Engineering of Microbial Polysaccharide Structures

Jochen Schmid
from: Microbial Exopolysaccharides: Current Research and Developments (Edited by: Özlem Ateş Duru). Caister Academic Press, U.K. (2019) Pages: 83-98.

Abstract

This review will deal with the structural diversity of bacterial (exo)polysaccharides based on the biosynthesis pathways and the highly specific glycosyltransferase proteins. Especially the so called Wzx/Wzy biosynthesis pathway will be explained in detail and the challenges and prospects of tailoring the chemical structures and thus polysaccharide properties will be highlighted. The differences of chemical modification and in-vivo modification will be discussed. Finally, genetic engineering approaches for altered chemical structures and enhanced productivities will be displayed and discussed to highlight challenges and prospective for engineering hetero- as well as homopolysaccharides read more ...
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