The Dengue Virus Replication Complex
Sven Miller, Ines Romero-Brey, and Ralf Bartenschlager
from: Frontiers in Dengue Virus Research (Edited by: Kathryn A. Hanley and Scott C. Weaver). Caister Academic Press, U.K. (2010)
Replication of all positive-stranded RNA viruses investigated so far occurs in close association with virus-induced intracellular membrane structures. Dengue virus (DENV), as a member of the family Flaviviridae, also induces such extensive rearrangements of intracellular membranes, called replication complex (RC). These RCs seem to contain viral proteins, viral RNA and host cell factors. However, the biogenesis of the RC and the three-dimensional organisation is to the most part unclear. In this chapter we summerize the current state of research as regards 1) the individual steps involved in DENV replication, 2) the viral and host cell proteins involved in DENV replication, 3) the intracellular sites of DENV replication, 4) the architecture of the DENV RCs and 5) the host cell nucleus and DENV replication. Finally, we present a hypothetical model of the biogenesis of the DENV replication complex read more ...