Improved Understanding of the Action and Genetics of Clostridium perfringens Enterotoxin Suggests Potential Applications for Cancer Therapy and Drug Delivery
Sameera Sayeed, Susan L. Robertson, Justin A. Caserta and Bruce A. McClane
from: Clostridia: Molecular Biology in the Post-genomic Era (Edited by: Holger Brüggemann and Gerhard Gottschalk). Caister Academic Press, U.K. (2009)
Clostridium perfringens enterotoxin (CPE) causes the intestinal symptoms of a common food-borne illness and ~5-15% of all antibiotic-associated diarrhea cases. In food poisoning isolates, the enterotoxin gene (cpe) is usually present on the chromosome, while cpe is carried by conjugative plasmids in antibiotic-associated diarrhea isolates. CPE action involves its binding to claudin receptors, oligomerization/prepore formation, and prepore insertion to form a functional pore that kills cells by apoptosis or oncosis. The C-terminal half of CPE mediates receptor binding, while its N-terminal half is required for oligomerization. CPE/CPE derivatives are being explored for cancer therapy/diagnosis and improved drug delivery read more ...