A Post-genomic View of Candida-host Cell Interactions
Michael C. Lorenz
from: Candida: Comparative and Functional Genomics (Edited by: Christophe d'Enfert and Bernhard Hube). Caister Academic Press, U.K. (2007)
The release of the complete genome sequence of Candida albicans has enabled the development of genomic technologies in this important pathogen. These tools have been used to investigate the genome-wide responses of C. albicans to conditions directly relevant to pathogenesis in in vitro systems, including stress responses, morphogenesis, and interactions with host cells, in particular, to cells of the immune system. The picture emerging from these studies is one of complexity as seen in two ways. First, the responses can be extensive (r)C phagocytosis by macrophages or neutrophils alters expression of hundreds of genes. Secondly, the response programs are very specific. C. albicans responds to oxidative stresses by inducing only antioxidant genes; the broad environmental stress response network identified in Saccharomyces cerevisiae appears to be completely absent in C. albicans. Similarly, transcript profiles following phagocytosis by macrophages or neutrophils have only limited overlap, indicating that C. albicans can recognize the different immune cells. This chapter discusses these studies and the implications of these findings in the pathogenesis and biology of this organism read more ...