Candida Cell Wall Proteins at the Host-Pathogen Interface
Margaret L. Zupancic and Brendan P. Cormack
from: Candida: Comparative and Functional Genomics (Edited by: Christophe d'Enfert and Bernhard Hube). Caister Academic Press, U.K. (2007)
During infection, the fungal cell surface, by its nature, is the first part of the cell to encounter the host. The fungal cell wall, therefore, is of vital importance in determining the nature and outcome of host-pathogen interactions. In different Candida species, proteins in the cell wall mediate a variety of cell-cell interactions important in virulence, including initial adherence to the host cell, uptake by certain mammalian cell types, and formation of biofilms. In addition, carbohydrate components of the cell wall serve as important modulators of the immune system. This chapter will examine the impact of Candida cell wall on overall virulence, focusing primarily on covalently attached cell wall proteins read more ...