Cell Wall Biology of Candida
Piet W.J. de Groot, Bernd W. Brandt and Frans M. Klis
from: Candida: Comparative and Functional Genomics (Edited by: Christophe d'Enfert and Bernhard Hube). Caister Academic Press, U.K. (2007)
Fungal cell walls play a crucial role in maintaining osmotic homeostasis and offer protection against mechanical damage; they also play a key role in the initial events that take place during the establishment of fungal infections. Cell wall architecture and biosynthesis have been extensively studied in Saccharomyces cerevisiae and later also in Candida albicans, resulting in a detailed molecular model of their walls. Genome sequencing of several Candida species has been completed or is in progress. We review here the current knowledge of Candida cell walls. We will also present a bioinformatics-based inventory of proteins either present in the cell walls, or involved in synthesis or modification of cell wall components, or in regulation of cell wall synthesis. These data will be integrated into a comprehensive picture of cell wall biology of Candida species read more ...