Stress Responses in Candida albicans
Janet Quinn and Alistair J.P. Brown
from: Candida: Comparative and Functional Genomics (Edited by: Christophe d'Enfert and Bernhard Hube). Caister Academic Press, U.K. (2007)
The virulence of the Candida albicans is dependent upon its ability to mount stress responses. This reflects the importance of these responses in protecting this fungal pathogen against host defenses. Recent genomic studies have contributed significantly to our understanding of stress responses in C. albicans and how they are regulated. It has become clear that C. albicans has diverged significantly from the benign model yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe with respect to the nature and regulation of its stress responses. C. albicans appears to utilize classical molecular mechanisms to protect itself against oxidative, osmotic, heat and heavy metal stresses. These include the synthesis of anti-oxidants, osmo-protectants and chaperones, for example. However, the Core Transcriptional Response to stress seen in C. albicans differs significantly from that observed in budding and fission yeasts. Furthermore, although key regulatory molecules are conserved in C. albicans, their contributions to the regulation of stress responses have diverged read more ...