Proteomics in Candida species
Aida Pitarch, Gloria Molero, Lucía Monteoliva, Derek. P. Thomas, José Luis López-Ribot, César Nombela and Concha Gil
from: Candida: Comparative and Functional Genomics (Edited by: Christophe d'Enfert and Bernhard Hube). Caister Academic Press, U.K. (2007)
Proteomics may significantly contribute towards a better understanding of the biological complexity encoded by the Candida genome and, in short, of Candida pathogenicity. From the first steps in the Candida proteome analysis in the early 1980s to the present time, the potential of this discipline to contribute to Candida investigations is being increasingly recognised. In fact, the recent availability of the complete C. albicans and C. glabrata genome sequences together with improvements in proteomics-based technologies are currently enabling the systematic characterization of the proteome for these two human pathogens. Remarkably, Candida proteome analyses have so far helped to unravel novel concepts in the cell envelope, virulence factors (including dimorphism and adhesion), host responses (antibody and macrophage responses) and drug resistance, among others. These results portend a near future in which proteomic technology is an indispensable tool in Candida research. It may be the rosetta stone that sheds light on certain Candida paradigms that are not predictable at this moment from genomic studies read more ...