Comparative Genomics of Candida Species
Geraldine Butler and Derek J. Sullivan
from: Candida: Comparative and Functional Genomics (Edited by: Christophe d'Enfert and Bernhard Hube). Caister Academic Press, U.K. (2007)
The complete genome sequences of Candida albicans and of four other hemiascomycetes (including C. glabrata and Debaryomyces hansenii) was reported in 2004. Currently, high quality draft sequence is either available or in progress for six species related to C. albicans, including C. dubliniensis, C. tropicalis, C. parapsilosis, Lodderomyces elongisporus, C. (or Pichia) guilliermondii, and C. (or Clavispora) lusitaniae. In addition sequencing the genome of a second isolate of C. albicans is also underway. This will generate an extremely valuable resource, as both pathogenic (C. albicans, C. tropicalis, C. parapsilosis, C. lusitaniae, C. glabrata) and non-pathogenic (D. hansenii, L. elongisporus, C. guilliermondii) are included. The species list also includes a number that are apparently asexual (such as C. albicans) and some that are fully sexual (such as C. guilliermondii and L. elongisporus). This chapter describes the progress of the various genome sequencing projects and their current status. The relationship and possible evolution of the Mating Type-Like locus is also discussed read more ...