Comparative Genomics in Hemiascomycetous Yeasts
Héloïse Muller, Bernard Dujon and Cécile Fairhead
from: Candida: Comparative and Functional Genomics (Edited by: Christophe d'Enfert and Bernhard Hube). Caister Academic Press, U.K. (2007)
The sequence of Sacharomyces cerevisiae, or baker's yeast, an omnipresent genetic model in research laboratories, was released in 1996, thanks to the work of multinational consortia. This was the first complete sequence of a eukaryotic organism, and led to the discovery of many new genes, paving the way for sequence analysis of its closest sibling species, the hemiascomycetes. Since then, many hemiascomycetes have been completely or partially sequenced, offering a unique panel of genomic sequences from phylogenetically close species. We review here the major features revealed by these sequences; genome size and gene number, chromosomal structures such as centromeres, telomeres and replication origins, and we discuss the evolutionary paths that led to differing genome compositions in these species, including the whole genome duplication that occurred in the Saccharomyces branch, chromosomal rearrangements and divergence in protein-coding genes read more ...