Caister Academic Press

The Mating Type Locus, Switching and Mating in Candida

David R. Soll
from: Candida: Comparative and Functional Genomics (Edited by: Christophe d'Enfert and Bernhard Hube). Caister Academic Press, U.K. (2007)


In 1999, the mating type-like (MTL) locus of Candida albicans was characterized, and in 2000, mating was demonstrated in vitro and in vivo. These discoveries demonstrated a functional mating system in C. albicans. In the years that followed, similarities to the Saccharomyces cerevisiae mating system were identified, but more interestingly, unique features were demonstrated, including a1-α2 repression of white-opaque switching, the requirement of a phenotypic switch from white to opaque to attain mating competency, the incorporation of the program of filamentation into the mating process, and the signaling of white cells by opaque cells through the release of pheromone, to form a biofilm presumably to facilitate mating. The mating system of Candida dubliniensis mimics that of closely related C. albicans, while that of Candida glabrata mimics that of closely related S. cerevisiae. The mating systems of C. albicans, C. dubliniensis and C. glabrata are reviewed with attention to the possible relationships they may have to pathogenesis read more ...
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