Bat Influenza A-like Viruses
Gert Zimmer, Veronika Götz, Kevin Ciminski, Sebastian Giese and Martin Schwemmle
from: Bats and Viruses: Current Research and Future Trends (Edited by: Eugenia Corrales-Aguilar and Martin Schwemmle). Caister Academic Press, U.K. (2020) Pages: 35-44.
Influenza A viruses (IAV) are highly contagious pathogens that can cause considerable mortality and morbidity in animals and humans. Until recently it had been believed that all IAV subtypes circulate in aquatic waterfowl; however, this understanding has recently been challenged with the discovery of two novel influenza A-like virus sequences in faeces from fruit-eating bats in Central and South America. Overall, these two new subtypes, provisionally designated H17N10 and H18N11, share many features with conventional IAVs, yet their surface glycoproteins lack the canonical receptor-binding and -destroying activity of the classical haemagglutinin and neuraminidase proteins, respectively. The identification of two novel IAV subtypes in combination with their currently unknown receptor raised the question of their potential zoonotic risk. Here, we summarize recent progress in the characterisation of these viruses read more ...