Caister Academic Press

Mycobacterium avium subspecies paratuberculosis: Are Mycobacteriophages the Answer?

Gillian Crowley, Colin Buttimer, Lorraine Endersen, Aidan Coffey and Jim O'Mahony
from: Bacterial Viruses: Exploitation for Biocontrol and Therapeutics (Edited by: Aidan Coffey and Colin Buttimer). Caister Academic Press, U.K. (2020) Pages: 383-418.


Johne's disease is a chronic wasting disease of ruminants and other animals. It impacts significantly on animal welfare and the livelihood of farmers. Due to the complexity of the causative organism (Mycobacterium avium ssp paratuberculosis), effective research into the detection and treatment of Johne's disease is problematic. Mycobacteriophages offer much hope on both fronts given their ubiquity in nature and their potential to target specific mycobacterial pathogens. This chapter traces the evolution of Johne's disease and catalogues the importance of mycobacteriophages. It also explores potential avenues of future research that may raise the hope of effectively treating the global problem of Johne's disease read more ...
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