Caister Academic Press

Bacteriophage Therapy in Food Animals

Yongping Xu, Huijun Geng, Xiaoyu Li, Bingdong Wei, Cong Cong, Xiaowen Sun and Jibin Li
from: Bacterial Viruses: Exploitation for Biocontrol and Therapeutics (Edited by: Aidan Coffey and Colin Buttimer). Caister Academic Press, U.K. (2020) Pages: 335-352.


In animals destined for food use, bacteriophages have considerable potential, both for biocontrol of zoonotic pathogens such as Campylobacter, E. coli and Salmonella and also for therapeutic uses in animal diseases in much the same way as phages applied to treat human infections. Nevertheless, animal phage applications theoretically face less stringent regulations than those faced in the human context. The success of phage application for controlling target bacteria in animals generally has similar biological hurdles to those in other application areas. These include the phage(s) having a broad host range covering many strains within a bacterial species associated with a particular disease and the ability to physically survive long enough to reach the target area in the animal. Also, successful phage selection for biocontrol and therapeutic applications requires reliable monitoring of the epidemiology of strains or serotypes of the problematic bacterial species in the field. The explorations of phage therapy in the major food animals are discussed in this article and the findings outlined show these biological agents have considerable promise as part of an integrated disease management strategy in food animals read more ...
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