Application of Bacteriophages in Human Therapy: Recent Advances at the George Eliava Institute
Nina Chanishvili, Lia Nadareishvili, Elisabed Zaldastanishvili, Nana Balarjishvili and Mzia Kutateladze
from: Bacterial Viruses: Exploitation for Biocontrol and Therapeutics (Edited by: Aidan Coffey and Colin Buttimer). Caister Academic Press, U.K. (2020) Pages: 223-256.
This chapter describes a variety of recent compassionate-case phage therapy interventions performed using the expertise of the staff at the George Eliava Institute. The cases described include a variety of complex problematic infections involving various skin locations, those with cystic fibrosis, physiologically damaged diabetic feet, post-transplant conditions and urinary tract complications. The most remarkable developments are the positive findings following the execution of a small-scale human clinical trial, one which leads to the successful completion of a large-scale double-blind, randomised controlled human clinical trial aimed at eliminating problematic urinary tract infection in patients intended for transurethral resection of the prostate. The necessity for pre-adaption of existing phage cocktails to target a particular spectrum of infectious pathogens is also discussed read more ...