Commercial Products for Human Phage Therapy
Nina Chanishvili and Marina Goderdzishvili
from: Bacterial Viruses: Exploitation for Biocontrol and Therapeutics (Edited by: Aidan Coffey and Colin Buttimer). Caister Academic Press, U.K. (2020) Pages: 203-222.
This article describes the development and distribution of early therapeutic bacteriophage (phage) products for the treatment of problematic bacterial infections before the advent of antibiotics. It details the beginnings of commercial phage production in Paris by Félix d'Hérelle in the 1920s leading subsequently to their production by L'Oréal, the manufacture of products in India to treat cholera, in Latin America to treat dysentery, and several in the USA by Ely Lilly to treat a range of infections up to the 1940s. It also discusses the various commercial products and the manufacturing approaches used to make them in the Republic of Georgia and throughout Russia from the Soviet period up to the present day, and details twenty-five commercial products for human phage therapy which are still officially registered there, most of which are widely purchased and used today. Genetic and metagenomic analysis of some of the latter products is discussed read more ...