Functional Systems Biology of Aspergillus
Christian Rank, Thomas O. Larsen and Jens C. Frisvad
from: Aspergillus: Molecular Biology and Genomics (Edited by: Masayuki Machida and Katsuya Gomi). Caister Academic Press, U.K. (2010)
The genus Aspergillus is known for an impressive array of outwards directed functional metabolites or extrolites. The most important of these are accumulated acids, secondary metabolites and extracellular enzymes, widely used in biotechnology and important for mammalian health. Aspergillus species are also used as transformation hosts and for bioremediation and bioconversions. Following the full genome sequencing of several species of Aspergillus , the fields of comparative genomics, transcriptomics, proteomics and metabolomics are now open for exploration. Annotation of the functions of the different genes and proteins and their interactions is, however, not always simple and we suggest that the fields of exometabolomics and exointeractomics should be more systematically explored read more ...