Caister Academic Press

Bioinformatics and Systems Biology of Aspergillus

Wanwipa Vongsangnak and Jens Nielsen
from: Aspergillus: Molecular Biology and Genomics (Edited by: Masayuki Machida and Katsuya Gomi). Caister Academic Press, U.K. (2010)


We present a review of systems biology studies (i.e. genomics, transcriptomics, proteomics, metabolomics and metabolic modeling) and bioinformatics of aspergilli. We summarize the current status of genome sequencing and Expressed Sequence Tag (EST) sequencing projects for different Aspergillus species. Nowadays, 15 Aspergillus genomes within ten species have been reported, 11 genomes were completely sequenced and publicly available and 4 genomes are ongoing sequencing projects. Beyond the genome, we further describe how this information can be applied to gain system level information. Using systems-wide techniques, we present different Aspergillus metabolic models which have been developed so far. Additionally, several transcriptomics studies have been published as well as there are some studies on proteomics and metabolomics of Aspergillus. Today bioinformatics and systems biology research is an important toolbox since it allows enhanced understanding of cellular mechanism of aspergilli and relevant fungi read more ...
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