Case Study: Chikungunya Virus
Lisa F.P. Ng
from: Alphaviruses: Current Biology (Edited by: Suresh Mahalingam, Lara Herrero and Belinda Herring). Caister Academic Press, U.K. (2016) Pages: 169-180.
The development of new and effective approaches to combat CHIKV infection is highly desirable. Molecular biology and genomic approaches could provide a brand new research paradigm. Nonetheless, to progress, potential drug candidates should also be extended to treat arthralgia and related chronic systemic inflammation induced by CHIKV. Whether these approaches will reach the clinic remains to be determined, but their success will rely on a better understanding of basic mechanisms of CHIKV infection and immunity. This chapter provides an overview of the cellular and molecular mechanisms of CHIKV pathogenesis and the various approaches leading to intervention read more ...