Caister Academic Press

Application of Alphavirus Vectors for Gene Therapy

Kenneth Lundstrom
from: Alphaviruses: Current Biology (Edited by: Suresh Mahalingam, Lara Herrero and Belinda Herring). Caister Academic Press, U.K. (2016) Pages: 157-168.


Alphavirus vectors based on Semliki Forest virus (SFV), Sindbis virus (SINV) and Venezuelan equine encephalitis virus (VEEV) have been engineered for efficient expression of heterologous proteins. In particular, SFV-based vectors have been frequently used for expression of membrane proteins in drug discovery. Likewise, SFV and SINV have been employed for numerous applications in neuroscience research due to their neurotrophic properties. Furthermore, all three alphaviruses have been used for vaccine development against infectious diseases and cancer. Alphavirus vectors have also found applications in gene therapy, especially in cancer therapy, due to their broad host range, high expression levels and transient nature. SINV vectors have demonstrated natural targeting to tumors whereas SFV vectors have been modified to enhance delivery to tumor tissue. Furthermore, oncolytic SFV vectors have been evaluated for increased therapeutic efficacy read more ...
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