Animal Models of Alphavirus-induced Inflammatory Disease
Lara J. Herrero, Adam Taylor, Pierre Roques, Brett A. Lidbury and Suresh Mahalingam
from: Alphaviruses: Current Biology (Edited by: Suresh Mahalingam, Lara Herrero and Belinda Herring). Caister Academic Press, U.K. (2016) Pages: 89-124.
Animal models that reflect key aspects of human disease are invaluable tools for understanding the mechanisms of disease pathogenesis and development of treatment strategies. In particular, animal models play important roles in expanding the current understanding of the pathobiology of alphavirus infection. Alphaviruses are arthropod-borne viruses that are able to infect a variety of vertebrate hosts. In humans, infection can result in extensive morbidity and mortality. As the global distribution of alphaviruses expands, with recent outbreaks in new areas of the world, there is an overwhelming need to improve our understanding of alphavirus pathogenesis with the key objective of anti-alphaviral drug design. This chapter focuses on the application of alphaviral animal models with particular emphasis on how these models have expanded the understanding of disease mechanisms and have provided a foundation for the development of new treatments read more ...