The Induction of Apoptosis by HSV-1
Christine M. Sanfilippo and John A. Blaho
from: Alpha Herpesviruses: Molecular and Cellular Biology (Edited by: R. M. Sandri-Goldin). Caister Academic Press, U.K. (2006)
Herpes simplex virus type 1 (HSV-1) is a cytolytic alphaherpesvirus which profoundly impacts its host cells. It is now widely recognized that consequences of HSV-1 infection include the induction of programmed cell death, also known as apoptosis, and the concomitant synthesis of proteins which act to block this process. While our current understanding of the precise mechanism by which apoptosis induction occurs remains elusive, several breakthrough studies have revealed much about how HSV-1 modulates the apoptotic process. In this chapter, we will review recent data focusing on the triggering of apoptosis by HSV-1, as well as evidence showing how this important human pathogen interferes with the fundamental cell death process read more ...