HSV-1 DNA Replication
Sandra K. Weller
from: Alpha Herpesviruses: Molecular and Cellular Biology (Edited by: R. M. Sandri-Goldin). Caister Academic Press, U.K. (2006)
Herpes Simplex Virus (HSV) DNA replication exhibits a complex relationship between DNA replication and recombination. In this respect HSV is similar to the large DNA bacteriophages, T4 and lambda which replicate via concatemers of tandemly repeated monomeric units using rolling circle replication as well as multiple pathways to carry out homologous recombination. The seven replication proteins of HSV may work in combination with both viral and cellular recombination proteins during this process, the details of which remain unclear. It appears that HSV DNA replication occurs in two stages. The first stage involves an origin-UL9 dependent step and in the second stage DNA replication may proceed in an origin-independent manner via a recombination-driven and/or rolling circle mechanism read more ...