Caister Academic Press

CIMB Abstract

Curr. Issues Mol. Biol. (2002) 4: 45-56.

An Overview of Toxicogenomics

Hisham K. Hamadeh, Rupesh P. Amin, Richard S. Paules and Cynthia A. Afshari

Toxicogenomics is a rapidly developing discipline that promises to aid scientists in understanding the molecular and cellular effects of chemicals in biological systems. This field encompasses global assessment of biological effects using technologies such as DNA microarrays or high throughput NMR and protein expression analysis. This review provides an overview of advancing multiple approaches (genomic, proteomic, metabonomic) that may extend our understanding of toxicology and highlights the importance of coupling such approaches with classical toxicity studies.

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