Caister Academic Press

Bacteriophages as antimicrobials

The increasing prevalence of multi-drug resistant bacterial pathogens has led to research to use phage as antimicrobials. The use of bacteriophages may offer an alternative treatment for infections. Phages have many potential applications in human medicine. Genetically engineered phage can be used to augment the antimicrobial efficacy of antibiotics and to reduce bacterial biofilms read more ...
This publication gives an overview of the different applications of bacteriophages. These include the use of whole virulent phages as antibacterials, recent advances in the development and applications of genetically modified phages, the use of phages as delivery vehicles and vaccines, and recent developments in the study and use of purified endolysins. Generally, it is clear that phages have a considerable array of potential applications as therapeutics in the modern medical and veterinary fields. In particular, the continued antibiotic resistance problem in clinically relevant micro-organisms calls for the exploitation of cheap, natural, readily-available, safe and efficient therapeutic agents. Phages exhibit characteristics which satisfy all of these criteria and their reintroduction as medical treatment options is worthy of strong consideration read more ...