Caister Academic Press

Sumoylation: Molecular Biology and Biochemistry

Publisher: Horizon Bioscience
Editor: Van G. Wilson Department of Medical Microbiology and Immunology, Texas A&M University, USA
Publication date: June 2004
ISBN-10: 0-9545232-8-8
ISBN-13: 978-0-9545232-8-2
Pages: x + 404

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Sumoylation is a novel post-translational modification system, biochemically analogous to, but functionally distinct from, ubiquitinylation. Sumoylation involves the covalent attachment of a SUMO (small ubiquitin-related modifier) to substrate proteins. This modification system has crucial roles in many different biological processes, including protein localization and stability, transcriptional activities, nucleocytoplasmic signalling and transport, and genome replication, as well as the regulation of gene expression. The molecular and biochemical mechanisms involved in sumoylation have been the subject of intense interest in recent years. This volume, edited and written by leading international experts, is the first book to be devoted to sumoylation. It presents information on the history, evolution and mechanisms of sumoylation, discusses SUMO proteases, ligases and conjugation pathways, and reviews the impact on modification and nucleocytoplasmic transport, PML nuclear bodies, and transcriptional regulation. In addition, specialist chapters cover the role of sumoylation in yeast, viruses and the tumor suppressor p53. This comprehensive book is the definitive reference volume on all aspects of sumoylation. It is an essential reference manual for all researchers interested in this area.


"A review of the field is very welcome ... this book does an excellent job ... reassuringly up-to-date ... an extremely useful resource for those working in the area." from Microbiology Today (2004) 31: 201.

Chapter List:

Chapter 1
Historical Introduction to SUMO Modification
Kirsten Jensen, Thomas Sternsdorf, Paul Freemont

Chapter 2
The Molecular Evolution of SUMO Proteins
Christopher N. Larsen and Alwin Köhler

Chapter 3
Molecular Mechanism of Sumoylation
Yuan Chen

Chapter 4
SUMO Proteases
Felicity Watts

Chapter 5
SUMO E3 Ligases
Andrea Pichler and Frauke Melchior

Chapter 6
Unraveling the SUMO-2/3 Conjugation and De-conjugation Pathways
Hisato Saitoh

Chapter 7
Sumoylation in Yeast
Yoshiko Kikuchi

Chapter 8
PML Nuclear Bodies and Sumoylation
Valérie Lallemand-Breitenbach and Hugues de Thé

Chapter 9
SUMO Modification and Nucleocytoplasmic Transport
Michael J. Matunis

Chapter 10
Control of Gene Expression by SUMO
David Girdwood, Michael H. Tatham and Ronald T. Hay

Chapter 11
Viruses and Sumoylation
Germán Rosas-Acosta and Van G. Wilson

Chapter 12
Sumoylation of Tumor Suppressor p53 and of its Ubiquitin Ligase, Mdm2
Hideyo Yasuda


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(EAN: 9780954523282)