Caister Academic Press

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PCR Troubleshooting: The Essential Guide   Ebook (PDF) for instant download Download PDF
Publisher: Caister Academic Press
Author: Michael L. Altshuler
Pages: 80
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A unique PCR troubleshooting guide that is an essential companion for anyone who uses the polymerase chain reaction technique. Aimed at a reader with some experience in PCR the book discusses the many and varied problems encountered with PCR together with tips, advice and procedures to obviate rather than overcome the PCR problems. Written in the language of the laboratory with a little humour and a down-to-earth approach, the book is easy to read and understand. If you fail at PCR, consult this book! The advice in these pages is invaluable and is the sort of advice that is not usually found elsewhere. In the words of the author, remember that there are many other things in life than PCR ... for example, isothermal DNA amplification.

Toxoplasma: Molecular and Cellular Biology   Ebook (PDF) for instant download Download PDF
Publisher: Horizon Bioscience
Editor: James W. Ajioka and Dominique Soldati
Pages: xx + 626 (plus colour plates)
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Written by internationally acclaimed researchers, this is the first book to provide a comprehensive coverage of this important parasite from both the host and pathogen perspectives. The book is divided into six main themes ranging from pathogenesis in humans to molecular details of parasite motility and invasion. Part 1 reviews the life cycle and ultrastructure of the parasite and provides a general framework for the subsequent chapters. The second part covers pathogenesis and immunity. The third section covers both Mendelian and molecular genetics and the latest genomic sequencing results, providing a fascinating insight into how host-pathogen interactions may shape the parasite's genome organization, population structure and evolution. The fourth section discusses the core cell biology of the parasite, exploring the relationship between cell cycle, gene expression, nutrient metabolism and developmental interconversion. The final two sections cover the novel sub-cellular and molecular devices of the parasite cell, the organelles and molecular processes characteristic of apicomplexan parasites, molecular motility, and invasion and occupancy of the host cell.

The Biofilm Mode of Life: Mechanisms and Adaptations   Ebook (PDF) for instant download Download PDF
Publisher: Horizon Bioscience
Editor: Staffan Kjelleberg and Michael Givskov
Pages: viii + 248 + 4 colour plates
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This book, written by leading international scientists, presents an overview of the most recent and exciting new research into the mechanisms that underpin the biofilm mode of life. This includes studies on interactions among biofilm cells, metabolic interactions, cell to cell communication and signal transmission across cells and species, competition and predation across species and domains, the use of modern molecular techniques and confocal laser scanning microscopy to study biofilm community structure and composition, mechanisms of biofilm dissolution, and genomic based studies.

Molecular Biology of Streptococci   Ebook (PDF) for instant download Download PDF
Publisher: Horizon Bioscience
Editor: Regine M. Hakenbeck and Singh Chhatwal
Pages: xiv + 578
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The genus Streptococcus is huge and encompasses a large variety of human and animal pathogenic and commensal bacteria. It is not known why some species are virulent and others not, and why even within one species, the virulence potential varies. These and other key questions are addressed in this timely book which draws on the recent advances in streptococcal genomics to provide an up-to-date coherent picture of the molecular and cellular biology of streptococci. With contributions from internationally renowned streptococcal researchers, this comprehensive book reviews all of the important topics. The book is divided into three sections: Streptococcus pneumoniae, Streptococcus spp. (group A and group B streptococci, oral streptococci and others), and Methods. Topics include: genetic transformation in S. pneumoniae, biologically active S. pneumoniae peptides, the pneumococcal cell wall, the capsular polysaccharides, virulence factors and adhesion proteins, genetic regulation of virulence, genome-wide screening for essential S. pneumoniae genes, molecular epidemiology, penicillin resistance, and much more. An important and useful feature of this book is the methods section. This contains information on a number of key streptococcal molecular genetic techniques which will be invaluable to the reader.

Bordetella: Molecular Microbiology   Ebook (PDF) for instant download Download PDF
Publisher: Horizon Bioscience
Editor: Camille Locht
Pages: x + 294
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This book gathers the contributions of the world's most knowledgeable investigators on the various aspects of Bordetella molecular biology. The chapters cover comparative genomics, molecular epidemiology, genetic regulation, molecular characterisation of important virulence factors, including adhesins, toxins, secretion systems, Bordetella phages, molecular aspects of bacterial physiology, and applications in biotechnology and vaccine research. The book is written by 28 scientists from ten different countries, all actively working in the field. The chapters cover a broad spectrum of Bordetella-related issues with a focus on molecular aspects. An essential book for anyone interested in Bordetella, pertussis, whooping cough, bacterial pathogenesis and vaccine development.

Computational Genomics: Current Methods   Ebook (PDF) for instant download Download PDF
Publisher: Horizon Bioscience
Editor: Nikola Stojanovic
Pages: xii + 234
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The book opens with an overview of the current state of comparative genomics and an account of the issues involved in the analysis of newly sequenced genomes. Other topics cover the recent methods used in the study of mobile DNA elements, motif finding and the characterization of segments within DNA sequences, theoretical considerations and techniques in the construction and analysis of sequence alignments, and the methods for processing microarray data. Also included is an overview of the computational issues involved in the study of the HIV virus. The last part of the book provides an overview of the resources and technologies aimed to facilitate core genomics research: databases and supercomputing applications, the focus being on emerging technologies such as the interconnecting of resources, the development of meta-databases and data exchange protocols. The book concludes with a review of networking technologies and resources, as well as some of the applications of distributed computing in genomics. An essential book for anyone involved in genomics or bioinformatics.

Nanotechnology in Therapeutics: Current Technology and Applications   Ebook (PDF) for instant download Download PDF
Publisher: Horizon Bioscience
Editor: Nicholas A. Peppas, J. Zach Hilt and J. Brock Thomas
Pages: x + 440
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The authors of this volume describe and discuss current technology and the applications of nanoparticles and nanostructures in various aspects of therapeutics and drug delivery. The chapters are completely up-to-date and are written by some of the leading scientists in the field. Topics covered include chronobiology, chronopharmacology and chronotherapeutics, polymeric gene delivery vectors, biohybrid materials, biomimetic systems, hydrogel nanocomposites, star polymers and dendrimers, ionic nanoparticulate systems, nanospheres and nanoparticles. Entire chapters are devoted to specific applications of nanotechnology such as cancer therapy, bone disorders, and diabetes. An essential book for anyone interested in the application of nanotechnology in medicine.

Burkholderia: Molecular Microbiology and Genomics   Ebook (PDF) for instant download Download PDF
Publisher: Horizon Bioscience
Editor: Tom Coenye and Peter Vandamme
Pages: x + 304
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This volume brings together the expertise and enthusiasm of an international panel of leading Burkholderia researchers to provide a state-of-the art overview of these important organisms. Topics covered include epidemiology, comparative genomics, antibiotic resistance, polysaccharides, beneficial interaction with plants, and much more. Each chapter is independent and can be read in isolation, but as a whole the book provides an important resource summarising our current knowledge of Burkholderia molecular biology and genomics. Essential reading for all researchers working with Burkholderia and related organisms, and recommended reading for other scientists working bacterial genomics, antibacterial research, bacterial molecular and cellular biology, environmental microbiology, and bioremediation.

Trypanosomes: After The Genome   Ebook (PDF) for instant download Download PDF
Publisher: Horizon Bioscience
Editor: David Barry, Richard McCulloch, Jeremy Mottram and Alvaro Acosta-Serrano
Pages: xii + 423
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In this book international experts review the contribution of trypanosome research to our understanding of eukaryote biology. Chapters are written from a molecular and genomic perspective and contain speculative models upon which to base future research efforts. Topics include: The genome of T. brucei, reverse and forward genetics, genetic exchange between trypanosomes, chromosome structure and dynamics, DNA replication, recombination and repair, transcription, post-transcriptional control of gene expression, cell structure, cell division and cell cycle, intracellular transport systems, cell surface architecture, antigenic variation, and comparative genomics of metabolism. The book provides an important resource summarising our current knowledge of trypanosome molecular and cellular biology. Essential reading for all researchers working with trypanosomes and related organisms and eukaryotic model organisms.

Salmonella: Molecular Biology and Pathogenesis   Ebook (PDF) for instant download Download PDF
Publisher: Horizon Bioscience
Editor: Mikael Rhen, Duncan Maskell, Pietro Mastroeni and John Threlfall
Pages: x + 194
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In this book internationally acclaimed experts review cutting-edge topics in Salmonella research. Chapters are written from a molecular perspective and provide a unique insight into the current status of Salmonella research. Topics include epidemiology, molecular typing, antibiotic resistance, host-interaction in the gut, adhesins, pathogenecity islands, virulence plasmids, gene regulation, biofilms, and microarray analysis. Essential reading for all researchers working with Salmonella and related organisms, and recommended reading for other scientists working bacterial genomics, molecular biology, antibacterial research, and bacterial molecular and cellular pathogenesis.

DNA Microarrays: Current Applications   Ebook (PDF) for instant download Download PDF
Publisher: Horizon Bioscience
Editor: Emanuele de Rinaldis and Armin Lahm
Pages: xii + 176 (+ 9 colour plates)
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This book focuses on the current successful applications of microarrays in various areas of bioscience. The authors describe the use of microarrays to assist basic research and drug discovery by the generation of gene expression maps, the reconstruction of gene networks and the study of biochemical pathways, the classification of genes and biological samples, and a real case study on the transcriptional effects of vaccine treatment. An entire chapter is dedicated to applications of microarrays that do not involve gene expression. This book is designed for researchers and students in all areas of biosciences.

Antimicrobial Resistance in Bacteria   Ebook (PDF) for instant download Download PDF
Publisher: Horizon Bioscience
Editor: Carlos Amabile-Cuevas
Pages: vi + 202
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This book presents nine comprehensive and cutting-edge reviews on the current state of antimicrobial resistance. Special emphasis is placed on state-of-the-art research and the authors focus on novel approaches and new perspectives. Topics covered include new antibiotics, biofilm resistance, drug efflux, plasmid-mediated resistance, extended-spectrum beta-lactamases, monitoring of resistance, predicting the evolution of new resistance, antibiotic cycling, and a review of the system for the discovery and development of novel antibiotics. The chapters are unified in theme, however each stands alone in conveying the author's individual perspectives on the issue of antimicrobial resistance. Written by experts in the field of antimicrobial resistance this book is a major new resource for microbiologists, molecular biologists, researchers, epidemiologists, infectious disease specialists, medical practitioners, public health experts, and anyone interested in a review of the current research on antimicrobial resistance.

Research and Applications in Bacteriocins   Ebook (PDF) for instant download Download PDF
Publisher: Horizon Bioscience
Editor: Margaret A. Riley and Osnat Gillor
Pages: vi + 218
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The authors in this book discuss the identification and characterisation of this diverse group of protein toxins and review the ever-increasing number of potential applications in human health, veterinary medicine, crop management, agriculture, food preservation and bioremediation. Topics covered include: biosynthesis, structure and function, genetic modification, cytotoxic activity, potential as antimicrobials, and applications in agriculture and veterinary health. An essential book for all scientists interested in antimicrobials, drug development, bacterial toxins, lactic acid bacteria.

Molecular Biology of the Flavivirus   Ebook (PDF) for instant download Download PDF
Publisher: Horizon Bioscience
Editor: Matthias Kalitzky and Peter Borowski
Pages: xii + 380
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Flaviviruses constitute a family of linear, single-stranded RNA(+) viruses. They cause approximately 70 different diseases which have a major impact on national economies and health authorities worldwide. With contribution from internationally acclaimed authors such as Ernest Gould and Hubert Blum, this book reviews the most significant cutting edge discoveries in the flavivirus field. Aspects of molecular biology common to flaviviruses are explored in depth. Topics include the evolution and function of flavivirus RNA, flavivirus replication, laboratory diagnosis and vaccine development. Individual chapters are devoted to the molecular biology of yellow fever virus, dengue virus, Japanese encephalitis virus, and hepatitis virus C virus. Essential reading for all flavivirus researchers and a recommended text for all virology laboratories.

Chlamydia: Genomics and Pathogenesis   Ebook (PDF) for instant download Download PDF
Publisher: Horizon Bioscience
Editor: Patrik Bavoil and Priscilla Wyrick
Pages: xiv + 542
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Chlamydia is the perfect pathogen, remaining elusive to the host by hiding within its cells and to the researcher by being refractory to laboratory analysis. However the recent revolution in genomics and molecular biology have made a great impact on chlamydia research. Every chapter in this volume draws on recently acquired genomic information. Written by the rising stars of chlamydial research, this comprehensive book covers literally every aspect of Chlamydia molecular and cellular biology. The book is divided into four sections: comparative and functional genomics, molecular and cellular pathogenesis, host responses and disease, emerging strategies for control. Topics covered include comparative genomics, genomics of environmental Chlamydia, regulation of gene expression, tryptophan metabolism, chlamydiaphage, and much more. Essential reading for all chlamydia researchers and recommended reading for other scientists working in bacterial molecular and cellular pathogenesis, bacterial genomics and antibacterial research.