Caister Academic Press

Epstein-Barr Virus

Publisher: Caister Academic Press
Edited by: Erle S. Robertson
Department of Microbiology and the Abramson Comprehensive Cancer Center, University of Pennsylvania Medical School, Philadelphia, Pennsylvania 19104, USA
Pages: xii + 770
Publication date: September 2005
ISBN: 978-1-904455-03-5
Price: GB £299 or US $250Buy book
Publication date: September 2005
ISBN: 978-1-913652-39-5
Price: US $319Buy ebook

Epstein-Barr virus (EBV) is a human gamma herpes virus that remains one of the most successful viral parasites known to man. It is the etiological agent of infectious mononucleosis and is the major biological cofactor contributing to a number of human cancers including B-cell neoplasms (e.g. Burkitt's lymphoma, Hodgkin's disease and immunoblastic lymphomas), certain forms of T-cell lymphoma, and some epithelial tumours (e.g. nasopharyngeal carcinomas and gastric carcinomas). The virus has the unique ability to persist in the infected, apparently healthy host for life. Understanding the molecular interaction between EBV and its human host, the ability of the virus to modulate the host immune system, its ability to 'hide' in B-memory cells and factors that trigger viral reactivation are fundamental to understanding the cellular and molecular pathogenesis of the virus. This is critical for the development of strategies for the prevention and control of infection and disease.

In this book, world renowned EBV experts provide a critical and comprehensive review of every aspect of this important virus. By integrating genetic, immunologic, and cell biologic approaches to elucidate pathogenesis, penetrating new insights into the molecular and cellular interaction between EBV and its human host have emerged. Topics covered include: Discovery, history and seroepidemiology, EBV and the immune response, EBV genetics, EBV infection and persistence, latency, lytic proteins and reactivation control, vaccine approaches, animal models, and the future of EBV studies. This is essential reading for all EBV virologists as well as clinical and research scientists working on oncogenic viruses.


"This book is well presented and comprehensive, with a good mix of topics. Each chapter is written by an acknowledged expert in the field" from THE LANCET Infectious Diseases (2006) 6: 138.

"... should join other books on herpesviruses on the shelves of all those involved in virological research." from THE LANCET Infectious Diseases (2006) 6: 138.

"... of interest to all researchers new to the field from postgraduate students to experienced postdoctoral fellows." from Microbiology Today (2006).

"... a comprehensive text to be used by investigators new to the EBV field." from Clinical Infectious Diseases (2006) 43: 668-670.

"This is a book to have at hand, whether one is uninitiated or has studied the virus for a lifetime." from New Eng. J. Med. (2006) 355: 2708-2709.

"This book will be of help to many established and new investigators studying EBV." from CAB Abstracts (2006).

"an impressive and comprehensive collation of work ... It is beautifully edited and provides the reader with a seamless and highly informative journey into EBV research." from Aus. J. Med. Sci. (2007) 28: 148.

Table of contents
1. The Origins of EBV Research: Discovery and Characterization of the Virus
M.A. Epstein
2. The Early Days of Epstein-Barr virus Research: The Henle Years
Harald zur Hausen
3. EBV and the Tumor Virus Context
George Klein
4. Sero Epidemiology of EBV and Associated Malignancies
Guy de Thé
5. Clinical Aspects of Epstein-Barr Virus Infection
Jeffrey I. Cohen
6. Epstein-Barr Virus and Oral Malignancies
Rona S. Scott, Cary A. Moody and John W. Sixbey
7. Epstein Barr Virus in the Pathogenesis of NPC
Nancy Raab-Traub
8. Hodgkin's Lymphoma: Molecular Pathogenesis and the Contribution of the Epstein-Barr Virus
P.G. Murray and L.S. Young
9. Endemic Burkitt's Lymphoma
Beverly E. Griffin and Rosemary Rochford
10. EBV and Breast Cancer: Questions and Implications
Irène Joab
11. Epstein-Barr Virus and Gastric Cancers
Dai Iwakiri and Kenzo Takada
12. Epstein-Barr Virus, Invasion and Metastasis
Tomokazu Yoshizaki, Naohiro Wakisaka and Joseph S. Pagano
13. Immune Response and Evasion in the Host-EBV Interaction
Christian Münz
14. EBV Induces an Endogenous Superantigen: Implications for Pathogenesis
Natalie Sutkowski and Brigitte T. Huber
15. Epstein-Barr Virus Genome
Paul J. Farrell
16. Strategies for Reverse Genetic Analysis of EBV
Kenneth M. Izumi
17. EBV Persistence and Latent Infection In Vivo
David A. Thorley-Lawson
18. EBV Entry and Epithelial Infection
Lindsey Hutt-Fletcher
19. The Plasmid Replicon of EBV: An Element That Underlies EBV's Transforming Functions
Amanda A. Mack and Bill Sugden
20. Regulation of EBV Latency-Associated Gene Expression
Samuel H. Speck
21. Role of EBERs
Kenzo Takada
22. EBNA2 Transcription Regulation in EBV Latency
Henrik Zetterberg and Lars Rymo
23. EBNA-2 and Notch Signalling
Bettina Kempkes, Lothar J. Strobl, Georg W. Bornkamm and Ursula Zimber-Strobl
24. Epstein-Barr Virus and the Cell Cycle
Jason S. Knight and Erle S. Robertson
25. Function of Latent Membrane Protein 2A
Masato Ikeda, Makoto Fukuda and Richard Longnecker
26. Epstein-Barr Virus Latent Infection Membrane Protein One
Ellen Cahir-McFarland and Elliott Kieff
27. EBV Lytic Infection
Bruce F. Israel and Shannon C. Kenney
28. Biological Role of The BARF1 Gene Encoded by Epstein-Barr Virus
Tadamasa Ooka
29. Post-transcriptional Gene Regulation by EBV SM Protein
Sankar Swaminathan
30. Developing Vaccines Against EBV-Associated Diseases
Denis J. Moss, Scott R. Burrows and Rajiv Khanna
31. Epstein Barr Virus Cell Based Immunotherapeutics
Gianpietro Dotti, Helen Heslop and Cliona Rooney
32. Epstein-Barr Virus Related Lymphocryptoviruses of Old and New World Nonhuman Primates
Fred Wang
33. Epstein-Barr Virus: Summary, Conclusions and a Forward Look
Alan Rickinson

How to buy this book

(EAN: 9781904455035 9781913652395 Subjects: [virology] [microbiology] [medical microbiology] [molecular microbiology] )