Frontiers in Dengue Virus Research
 | Edited by: Kathryn A. Hanley and Scott C. Weaver Published: 2010 ISBN: 978-1-904455-50-9 Price: GB £159 or US $319 Dengue virus (DENV), a mosquito-borne flavivirus, is the causative agent of dengue fever, currently one of the most significant emerging disease challenges to global public health. Although dengue is an old disease, recent decades have seen an unprecedented increase in the geographic range, incidence, and severity of infection. The virus infects 100 million people annually and is endemic in many tropical and sub-tropical regions in the world. At present, neither a licensed vaccine nor anti-viral drugs are available to control dengue disease, prompting a plethora of research initiatives aimed at understanding the molecular and cellular virology, genomics, and evolution of this important virus. This book brings together a panel of expert dengue virologists to produce a timely review of the rapidly expanding dengue research literature. In addition authors identify the most pressing questions that remain to be answered, thus providing a stimulus for future research. Topics include: evolutionary history, epidemiology, translation and processing of the viral polyprotein, viral replication, the role of the viral untranslated regions, pathogenesis, host response to DENV, development of animal models, DENV-mosquito interactions, dynamics of dengue virus transmission, emergence of DENV from its ancestral, sylvatic cycle, vaccines, novel anti-dengue drugs, and passive immunotherapy. Essential reading for every dengue virologist and highly recommended for all flavivirus and arbovirus virologists. read more ... |
"an up-to-date and cutting-edge anthology from the leading experts in the dengue field. The chapters are balanced by contributions from established investigators who have dedicated their careers to DENV research with those from newcomers who have recently made significant contributions the study of DENV. ... the book addresses a range of important topics in DENV research. The authors identify many important questions that remain to be answered. The book will be considered as an important reference to DENV and other flavivirus researchers at the graduate level and beyond." from Expert Review of Vaccines (February 2010)
"a reference for scientists studying arboviruses and infections. Chapters are well written with very little overlap. It would be a good investment for laboratories interested in arboviral diseases" from Doodys (2010) "well-organized and informative, yet highly accessible ... a thorough and up-to-date account ... a valuable point of reference" from David Sharpley (University of Liverpool, UK) writing in Microbiology Today
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