Caister Academic Press

Trypanosomes: After The Genome

Publisher: Horizon Bioscience
Editor: David Barry, Richard McCulloch, Jeremy Mottram and Alvaro Acosta-Serrano Wellcome Centre for Molecular Parasitology, University of Glasgow, Glasgow G12 8QQ, UK
Publication date: January 2007
ISBN: 978-1-904933-27-4 (hardback)
ISBN: 978-1-904933-42-7 (ebook)
Pages: xii + 423

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Trypanosomes cause medically and economically severe diseases such as Sleeping Sickness and Chagas' Disease in humans and Nagana in cattle. They are also inherently interesting scientifically, being single-cell eukaryotes under constant, strong diversifying selection. The publication of the genome sequences of two key trypanosomes, Trypanosoma brucei and Trypanosoma cruzi, in 2005 has provided an exciting new resource to improve our understanding of the molecular and cellular biology of these important parasites and aid the development of new drugs and vaccines. The genome sequences, allied with useful genetic tools and easy molecular manipulation, will consolidate T. brucei as a eukaryotic model organism. As a model, it has the added advantage that studies in this area are directly applicable to understanding and prevention of disease. Research in this area has never been more exciting.

In this book international experts review the contribution of trypanosome research to our understanding of eukaryote biology. Chapters are written from a molecular and genomic perspective and contain speculative models upon which to base future research efforts. Topics include: The genome of T. brucei, reverse and forward genetics, genetic exchange between trypanosomes, chromosome structure and dynamics, DNA replication, recombination and repair, transcription, post-transcriptional control of gene expression, cell structure, cell division and cell cycle, intracellular transport systems, cell surface architecture, antigenic variation, and comparative genomics of metabolism. The book provides an important resource summarising our current knowledge of trypanosome molecular and cellular biology.

Essential reading for all researchers working with trypanosomes and related organisms and eukaryotic model organisms.

Chapter List:

Chapter 1: The Genome of Trypanosoma brucei
Christiane Hertz-Fowler, Hubert Renauld and Matthew Berriman

Chapter : Reverse and Forward Genetics as Practical Approaches for Post-genome Studies
James C. Morris, Meredith T. Morris, Sylvia Y. Lee, William P. Toole, Clarice M. Seifert, and Alvaro Acosta-Serrano

Chapter 3: The System of Genetic Exchange in Trypanosoma brucei and other Trypanosomatids
Annette MacLeod, Mike Turner and Andy Tait

Chapter 4: Chromosome Structure and Dynamics.
Hubert Renauld, John M. Kelly and David Horn

Chapter 5: The Three R's of the Trypanosomatid Genomes: Replication, Recombination and Repair.
Michele M. Klingbeil, Peter Burton, Rebecca Barnes and Richard McCulloch

Chapter 6: Transcription in Trypanosomes: A Different Means to the End
Arthur Günzl, Luc Vanhamme, and Peter J. Myler

Chapter 7: Post-Transcriptional Control of Gene Expression in African Trypanosomes
Edward F. Hendriks and Keith R. Matthews

Chapter 8: Cell Structure, Cell Division and Cell Cycle
Tansy C. Hammarton, Bill Wickstead and Paul G. McKean

Chapter 9: Intracellular Transport Systems in Trypanosomes: Function, Evolution and Virulence
Markus Engstler, James D. Bangs and Mark C. Field

Chapter 10: Comparison and Evolution of the Surface Architecture of Trypanosomatid Parasites
Alvaro Acosta-Serrano, Clyde Hutchinson, Ernesto S. Nakayasu, Igor C. Almeida, and Mark Carrington

Chapter 11: Antigenic Variation in Trypanosoma brucei
Etienne Pays, Didier Salmon, Liam J. Morrison, Lucio Marcello and J. David Barry

Chapter 12: Comparative Genomics of Trypanosome Metabolism
Michael L. Ginger, Alan H. Fairlamb and Fred R. Opperdoes

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(EAN: 9781904933274)