Caister Academic Press

Toxoplasma: Molecular and Cellular Biology

Publisher: Horizon Bioscience
Editor: James W. Ajioka and Dominique Soldati of the Department of Pathology, Cambridge University, Tennis Court Road, UK and the Department of Microbiology and Molecular Medicine, University of Geneva, Switzerland respectively
Publication date: July 2007
ISBN: 978-1-904933-34-2 (hardback)
ISBN: 978-1-904933-35-9 (ebook)
Pages: xx + 626 (plus 6 colour plates)

How to Order . Download PDF of entire book

Toxoplasma gondii, once an obscure protozoan parasite, has recently become the focus of intense research, both as a serious pathogen in its own right and as a model member of the phylum Apicomplexa. This parasite causes congenital birth defects, is an important opportunistic pathogen associated with AIDS, and a serious veterinary concern. In addition the experimental accessibility of this parasite has allowed its development into an outstanding model for studying related species, including Plasmodium (the causative agent of malaria), Cryptosporidium (a devastating AIDS pathogen for which no effective therapy is available), and numerous veterinary pathogens.

Written by internationally acclaimed researchers, this is the first book to provide a comprehensive coverage of this important parasite from both the host and pathogen perspectives. The book is divided into six main themes ranging from pathogenesis in humans to molecular details of parasite motility and invasion. Part 1 reviews the life cycle and ultrastructure of the parasite and provides a general framework for the subsequent chapters. The second part covers pathogenesis and immunity. The third section covers both Mendelian and molecular genetics and the latest genomic sequencing results, providing a fascinating insight into how host-pathogen interactions may shape the parasite's genome organization, population structure and evolution. The fourth section discusses the core cell biology of the parasite, exploring the relationship between cell cycle, gene expression, nutrient metabolism and developmental interconversion. The final two sections cover the novel sub-cellular and molecular devices of the parasite cell, the organelles and molecular processes characteristic of apicomplexan parasites, molecular motility, and invasion and occupancy of the host cell.

The authors of this book describe in detail the biological characteristics that make T. gondii and related apicomplexans the most common and successful group of parasites on earth. Essential reading for all researchers working with Toxoplasma and related apicomplexans.

Chapter List:

Part 1 - Overview

Chapter 1: The Life Cycle of Toxoplasma gondii
J. P. Dubey

Chapter 2: Ultrastructure
J.-F. Dubremetz and D. J. P. Ferguson

Part 2 - Pathogenesis, Immunology and Virulence

Chapter 3: Epidemiology, Diagnostics and Chemotherapy
Eskild Petersen

Chapter 4: Ocular Toxoplasmosis: Clinical Features, Pathology, Pathogenesis, Animal Models and Immune Responses
Fiona Roberts, Annie Kuo, Leigh Jones, Rima McLeod and Craig Roberts

Chapter 5: Congenital Toxoplasmosis
A.W. Pfaff, O. Liesenfeld and E. Candolfi

Chapter 6: Innate Recognition and the Regulation of Protective Immunity to Toxoplasma gondii
Marion Pepper and Christopher A. Hunter

Chapter 7: Mechanisms of Immune Evasion
Eric Y. Denkers, Chiang W. Lee, Leesun Kim and Barbara A. Butcher

Chapter 8: Apoptosis and Its Impact on the Parasite-host Interaction
Carsten G. K. Lüder

Chapter 9: Pathogenicity and Virulence in Toxoplasma gondii
Sonya Taylor, Asis Khan, Chunlei Su, and L. David Sibley

Chapter 10: Cellular Response to Infection
Ashley Fouts and John C. Boothroyd

Part 3 - Genome and Genetics

Chapter 11: Genetics and Genome Organization of Toxoplasma gondii
Asis Khan, Sonya Taylor, Chunlei Su, L. David Sibley, Ian Paulsen, and James W. Ajioka

Chapter 12: Evolution and Comparative Genomics of Toxoplasma gondii
Jessica Kissinger and Chih-Horng Kuo

Chapter 13: Population Genetics, Sex and the Emergence of Clonal Lines of Toxoplasma gondii
Michael E. Grigg

Chapter 14: Manipulating the Genome
Marc-Jan Gubbels, Jolly Mazumdar, Giel van Dooren, and Boris Striepen

Part 4 - Growth, Development and Metabolism

Chapter 15: Cell Cycle Control/Parasite Division
Michael W. White, Jay R. Radke, Magnolia Conde de Felipe, and Margaret Lehmann

Chapter 16: Gene Regulation and Bradyzoite Development
Stanislas Tomavo and Louis M. Weiss

Chapter 17: Biology of Bradyzoites
Florence Dzierszinski and Laura J. Knoll

Chapter 18: Chromatin Remodeling
William J. Sullivan, Jr.

Chapter 19: Lipid Synthesis and Uptake
Isabelle Coppens

Chapter 20: Nucleotides and Amino Acids
Barbara A. Fox, Kshitiz Chaudhary, and David J. Bzik

Part 5 - Organelles: Sorting, Content and Function

Chapter 21: Protein Targeting to the Apicoplast
Marilyn Parsons Amy DeRocher, and Jean Feagin

Chapter 22: The Metabolic Functions of the Mitochondrion and the Apicoplast
Frank Seeber and Dominique Soldati

Chapter 23: Microneme Protein Repertoire and Function
M.-H. Huynh and V.B. Carruthers

Chapter 24: Proteomic Analysis of the Rhoptry Organelles of Toxoplasma gondii
J.M. Wastling and P.J. Bradley

Chapter 25: Dense Granules of the Infectious Stages of Toxoplasma gondii: Their Central Role in the Host/Parasite Relationship
Corinne Mercier, Marie-France Cesbron-Delauw and David J.P. Ferguson

Chapter 26: Calcium Homeostasis and Acidocalcisomes in Toxoplasma gondii
Silvia N.J. Moreno, Kildare Miranda and Wanderley de Souza

Part 6 - Cytoskeleton, Signaling, Motility and Invasion

Chapter 27: Tubulin, Microtubules and Microtubule-Associated Structures in Toxoplasma gondii
Naomi S. Morrissette

Chapter 28: Molecular Motors
Bernardo J. Foth and Dominique Soldati

Chapter 29: Actin Dynamics and Motility in Apicomplexans
Jennifer L. Gordon, Nivedita Sahoo, Simren Mehta, L. David Sibley

Chapter 30: Proteases of Toxoplasma gondii
Artemio Jongco and Kami Kim

Chapter 31: The Toxoplasma gondii Parasitophorous Vacuole Membrane: Transactions at the Parasite Host Interface.
Angela M. Martin and Anthony P. Sinai

How to buy this book

(EAN: 9781904933342)