Caister Academic Press

Antimicrobial Peptides in Human Health and Disease

Publisher: Horizon Bioscience
Editor: Richard L. Gallo University of California, San Diego
Publication date: March 2005
ISBN-10: 1-904933-10-6
ISBN-13: 978-1-904933-10-6
Pages: x + 374

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Antimicrobial peptides rapidly and directly inhibit infection by microbes and are of enormous importance in the body's natural defence against disease. In addition the role of antimicrobial peptides in the development of therapeutic agents for the prevention and treatment of disease is becoming increasingly important. Written by the leaders in the field this book provides an understanding of the implications of antimicrobial peptides in human disease. The volume is divided into sections containing reviews of specific families of antimicrobials, select organ systems that have demonstrated a relevance for antimicrobial peptides and, in addition, a more global discussion of these peptides and organs from distinct perspectives. Alternatively, each chapter can stand on its own, providing the reader with the ability to dive right into the subject of most interest. Topics covered include cathelicidins, alpha and beta defensins, granulysin, hepcidin, the role of antimicrobial peptides in blood, gut, skin, lung and in the oral environment. A recurring theme is the possibility of creating therapeutics that induce the expression of endogenous antimicrobial peptides for the prevention or treatment of disease. Essential reading for immunologists, microbiologists and all scientists with an interest in antimicrobial agents.

Reviews:

"This book represents a cutting edge summary of one of the most important fields in innate immunity." by CAB International (2005).

Chapter List:

Introduction
General Concepts of Antimicrobial Peptides, Past and Future
Michael Zasloff

Section 1: Select Diverse Peptides with Antimicrobial Action in Humans

Chapter 1
The Role of Cathelicidins in the Innate Host Defences of Mammals
Margherita Zanetti

Chapter 2
The Role of Alpha and Beta Defensins in Human Defense
Jens-Michael Schršder

Chapter 3
Granulysin
Steffen Stenger and Robert L. Modlin

Chapter 4
Hepcidin
Tomas Ganz

Section 2: Tissues and their use of Antimicrobial Peptides

Chapter 5
Antimicrobial Peptides in Human Blood
Gudmundur H. Gudmundsson and Birgitta Agerberth

Chapter 6
The Role of Paneth Cell a-Defensins in Enteric Innate Immunity
Andre J. Ouellette and Charles L. Bevins

Chapter 7
Antimicrobial Peptides in the Lung
Christoph Beisswenger and Robert Bals

Chapter 8
Antimicrobial Peptides in the Oral Environment: Expression and Function in Health and Disease
Beverly A. Dale and L. Page Fredericks

Chapter 9
Natural Antimicrobial Peptides: A Barrier against Human Skin Infection
Mohamed Zaiou, Richard L. Gallo and Marissa H. Braff

Section 3: Clinical Concepts

Chapter 10
Antimicrobial Peptide Resistance in Human Bacterial Pathogens
Victor Nizet

Chapter 11
A Pediatric Perspective on Antimicrobial Proteins and Peptides: Expression, Function, and Clinical Relevance
Ofer Levy

Chapter 12
Therapeutic Applications of Innate Immunity Peptides
Lijuan Zhang, Scott M. Harris and Timothy J. Falla

How to buy this book

(EAN: 9781904933106)