Caister Academic Press

Ebola and Marburg Viruses: Molecular and Cellular Biology

Publisher: Horizon Bioscience
Editor: Hans-Dieter Klenk and Heinz Feldmann Institute for Virology, Marburg and Canadian Science Centre, Winnipeg
Publication date: January 2004
ISBN: 978-0-9545232-3-7 (hardback)
ISBN-13: 978-1-904933-49-6 (ebook) Buy ebookAvailable now!

Pages: x + 370

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Ebola and Marburg viruses cause severe haemorrhagic fevers. Much research has been performed in recent years on the molecular and genetic properties of these viruses and in particular has focused on molecular structure, replication and virus-host interactions. This book presents a comprehensive review of the current research on these highly virulent viruses. Topics covered include the genomics and molecular biology of filoviruses, pathogenesis, replication, epidemiology, pathogenicity, approaches to vaccine development, virus-host interactions and the immune response.

Reviews:

"This book presents a comprehensive review of curent research on Ebola and Marburg viruses .... Researchers and students alike will find this book very useful." from CAB Abstracts.

"This book is expensive, but of outstanding value. It is highly recommended to all virologists and infectious disease physicians as well as to molecular biologists, immunologists and interested vaccinologists." from Microbiology Today (2004) 31: 103.

"Programs in infectious disease, international health and veterinary and zoonotic diseases will want to have this book in their collections. It is recommended for all biology and biomedical science library collections." from E-Streams (2004) 7(8). Reviewed by: Kristine M. Alpi, Lecturer in Public Health, Weill Medical College of Cornell University.

"Presents an extensive review of historical and current research on Ebola and Marburg viruses ... recommended for academic and special libraries" from E-Streams (2004) 7(12). Reviewed by: Beth Thomsett-Scott, Science librarian, University of North Texas Science and Technology Library.

"This is an excellent reference for anyone doing research with these viruses as well as for educators in virology." from Doody's Book Reviews. Reviewed by: Richard J. Baltaro, MD, PhD (Creighton University School of Medicine).

Preface:

Filoviruses are among the most serious human pathogens. They were discovered in 1967 when an outbreak of viral hemorrhagic fever was reported among laboratory workers in Europe who had been exposed to tissues and blood from African green monkeys (Cercopithecus aethiops). The causative agent was called Marburg virus. Almost a decade later, in 1976, another filoviruses, Ebola virus, was discovered as the cause of outbreaks of viral hemorrhagic fevers in Sudan and the Democratic Republic of the Congo (formerly Zaire). Until the mid 1990's outbreaks were sporadic, but this has changed in the recent past with outbreaks occurring almost annually in Central African countries.

When exported from the endemic areas, filoviruses, like other emerging exotic pathogens, become a public health problem in other parts of the world. Furthermore, Marburg and Ebola viruses have been used in former weapon programs and are now of considerable concern as potential bioterrorist agents. The lack of pre- and post-exposure intervention makes the development of rapid diagnostics, new antivirals and protective vaccines a priority for the preparedness of many nations. Further insight into the molecular biology, immunology and pathogenesis of filoviruses will promote these urgently needed deliverables.

A major drawback in the past has been the biocontainment needed for performing research on filoviruses and other related hemorrhagic fever viruses. Building new facilities is one way to respond, and the political support is mostly guaranteed in crisis situations. Aside from maintaining facilities and long-term funding, providing well-trained personnel becomes a critical issue. With the advent of DNA technology, however, substantial scientific progress has been made in recent years. There is now detailed knowledge of the structure and replication of these viruses. We are beginning to understand some of the mechanisms underlying pathogenicity. New diagnostic tools are being developed that should give a better insight into the ecology and epidemiology of these viruses, and there are new immunization strategies with a promise of a prophylactic potential.

This book is devoted to summarizing the past and more recent advances in molecular and cellular biology of Marburg and Ebola viruses. It also outlines and discusses new strategies for future research on these important human pathogens.

Marburg and Winnipeg, July 2003

Hans-Dieter Klenk, M.D. Professor, Department Head Institut für Virologie Philipps-Universität Marburg, Germany

Heinz Feldmann, M.D. Head, Special Pathogens Program National Microbiology Laboratory, Health Canada and Professor, Department of Medical Microbiology University of Manitoba, Winnipeg, Canada

Chapter List:

Chapter 1
Genome Organization, Replication, and Transcription of Filoviruses
Elke Mühlberger

Chapter 2
Structure of Viral Proteins
Winfried Weissenhorn

Chapter 3
Structural and Functional Polymorphism of the Glycoproteins of Filoviruses
Viktor E. Volchkov, Valentina A. Volchkova, Olga Dolnik, Heinz Feldmann, Hans-Dieter Klenk

Chapter 4
Molecular Mechanisms of Filovirus Entry
Stephen Y. Chan and Mark A. Goldsmith

Chapter 5
Roles of Filoviral Matrix- and Glycoproteins in the Viral Life Cycle
Gabriele Neumann, Takeshi Noda, Ayato Takada, Luke D. Jasenosky, and Yoshihiro Kawaoka

Chapter 6
Virus Maturation
Larissa Kolesnikova and Stephan Becker

Chapter 7
Filovirus Pathogenesis in Nonhuman Primates
Thomas W. Geisbert, Peter B. Jahrling, Tom Larsen, Kelly J. Davis, and Lisa E. Hensley

Chapter 8
Ebola Virus Infection in the Guinea Pig
Elena Ryabchikova, Margarita Smolina, Antonina Grajdantseva, Jurii Rassadkin

Chapter 9
Pathogenesis of Filovirus Infection in Mice
Mike Bray

Chapter 10
The Role of Endothelial Cells in Filovirus Hemorrhagic Fever
Hans-J. Schnittler, Ute Ströher, Tatiana Afanasieva, and Heinz Feldmann

Chapter 11
Modulation of Innate Immunity by Filoviruses
Christopher F. Basler and Peter Palese

Chapter 12
Cellular and Molecular Mechanisms of Ebola Pathogenicity and Approaches to Vaccine Development
Gary J. Nabel, Nancy J. Sullivan, and Zhi-yong Yang

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