Caister Academic Press

Bordetella: Molecular Microbiology

Publisher: Horizon Bioscience
Editor: Camille Locht INSERM U629 and Institut Pasteur de Lille, France
Publication date: May 2007
ISBN: 978-1-904933-31-1 (hardback)
ISBN: 978-1-904933-38-0 (ebook)
Pages: x + 294

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Species of the Bordetella genus are the causative agents of pertussis or whooping cough. It is almost twenty years since the last book totally devoted to Bordetella was published. Since then, research on Bordetella has made extensive use of molecular biology approaches, including genomics and post-genomics, and an enormous amount of new information has become available. World-wide, pertussis still kills between 200,000 and 400,000 children each year, and the disease still ranks 6th among the causes of death due to infection. A more profound molecular understanding of Bordetella may ultimately help to better control the disease.

This book gathers the contributions of the world's most knowledgeable investigators on the various aspects of Bordetella molecular biology. The chapters cover comparative genomics, molecular epidemiology, genetic regulation, molecular characterisation of important virulence factors, including adhesins, toxins, secretion systems, Bordetella phages, molecular aspects of bacterial physiology, and applications in biotechnology and vaccine research.

The book is written by 28 scientists from ten different countries, all actively working in the field. The chapters cover a broad spectrum of Bordetella-related issues with a focus on molecular aspects.

An essential book for anyone interested in Bordetella, pertussis, whooping cough, bacterial pathogenesis and vaccine development.

Chapter List:

Chapter 1
Speciation in the Genus Bordetella as Deduced from Comparative Genome Analyses
Andrew Preston, Louise Temple, Mohammed Sebaihia, Julian Parkhill and Duncan J. Maskell

Chapter 2
Phylogeny, Evolution and Epidemiology of Bordetellae
Frits R. Mooi, Qiushui He and Nicole Guiso

Chapter 3
The Bvg Regulon
Scott Stibitz

Chapter 4
The Bordetella Adhesins
Françoise Jacob-Dubuisson and Camille Locht

Chapter 5
Bordetella Toxins
Erik L. Hewlett and Gina M. Donato

Chapter 6
Type III Secretion in Bordetella Subspecies
Natalia A. Kozak, Ekaterina M. Panina and Jeff F. Miller

Chapter 7
The Ptl Type IV Secretion System
Amy A. Rambow-Larsen and Alison A. Weiss

Chapter 8
Primary Metabolism and Physiology of Bordetella Species
Sandra K. Armstrong and Roy Gross

Chapter 9
Bordetella Bacteriophage and Diversity-Generating Retroelements
Asher Hodes, Roman Barbalat, Louise Temple and Jeff F. Miller

Chapter 10
Biotechnological Applications of the Bordetella pertussis Adenylate cyclase toxin
Marcela Simsova, Gouzel Karimova, Peter Sebo and Daniel Ladant

Chapter 11
Pertussis Vaccines
Jann Storsaeter, Joanne Wolter and Camille Locht

How to buy this book

(EAN: 9781904933311)